[OFER-TRABEC] NAC: Beca predoctoral: Microvascular injury in heart

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---Procedencia:
Institución:Institut de Recerca Hospital Vall d'Hebron
Contacto correo-e:ibarba@ir.vhebron.net
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Microvascular injury in reperfused myocardium: from tissue edema to cardiac rupture

Reperfusion of ischemic myocardium aggravates necrotic cell death of myocytes and apoptotic cell death of coronary endothelial cells (Piper & Garcia-Dorado, Cardiovasc Res. 2009). After acute myocardial infarction, remodeling may occur leading to heart failure and, ultimately, to death. Increasing microvasculature reduces remodeling and may be important as concomitants to other therapeutic approaches such as stem-cell implants.
The aim of the present study is the design of strategies that can ultimately be applied to patients in order to reduce microvasculature death and/or promote its development after ischemia-reperfusion injury; test them in vitro, ex-vivo (perfused hearts, aortic rings) and in in-vivo animal models (roedent) and to evaluate its efficacy using, among others echocardiography, MR imaging and MR spectroscopy.
Mechanistic processes leading to microvasculature death and protection will be studied and integrated into a systems biology approach including genomic, proteomic and metabolomic data as well as live single-cell (confocal microscopy) and whole organ (Langendorff perfusion) physiology.
Parts of this project will be conducted in the Department of Physiology, University of Giessen Cardiovascular Research Center, Faculty of Medicine, Justus-Liebig-University, Giessen, Germany.

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Información complementaria de la oferta:
Supervisors: Dr. Ignasi Barba and Dr. David Garcia-Dorado

Lab Cardiologia Experimental
Hospital Universitari Vall d'Hebron,
Institut de Recerca (VHIR),
Universitat Autònoma de Barcelona,
Passeig Vall d'Hebron 119-129
08035 Barcelona, Spain
http://www.ir.vhebron.net
http://cardioexperimentalvh.onmedic.org

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