viernes, 23 de enero de 2015

[OFER-TRABEC] NAC: Postdoc position

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Institución:Stellenbosch University, South Africa
The Evolutionary Genomics Group at Stellenbosch University has a post-doctoral position available in the Department of Botany and Zoology to investigate the origin, structural organization (architecture) and genomic plasticity of the meiotic genomes of African antelope. Large-scale chromosomal changes such as inversions, translocations, fusions and fissions "reshuffle" genomic segments providing new chromosomal forms on which natural selection can work. Since these new forms are produced in the germ line they can, at least potentially, be fixed in populations thereby providing new heritable allelic variants that are essential for the maintenance of genetic diversity (Heredity 108 (1): 28-36).

There is extensive karyotypic diversity among African antelope where genomic reshuffling is often rapid and many closely related species possess different karyotypes indicating that chromosomal differentiation often occurs during, or shortly after cladogenesis. Our recent data suggest that the number of meiotic DSBs initiated in the early stages of meiosis and the final crossover events are influenced by how the genome is organized into chromosomes, and that there is a phylogenetic component in recombination rates (Proc Biol Sci 280(1771):20131945). This appears to be directional, strongly punctuated and subject to selection. However, the mechanism(s) underlying this remain elusive and one of the aims of this investigation will be to determine if antelope species (with lower RR due to chromosomal fusions) similarly show a lower number of ZnF repeats suggesting that some Rb fusions may be result in a modification of PRDM9 or its promotors and thus facilitate speciation.

The ideal candidate will have a published track record in molecular cytogenetics, especially in meiosis. A strong background in one or more the following areas would be advantageous:
• comparative genomics
• molecular systematics
• bioinformatics

The incumbent will work closely with researchers in two other groups: Dr Aurora Ruiz-Herrera (Universitat Autònoma de Barcelona, Spain, and Professor Jiri Rubes (Veterinary Research Institute, Czech Republic) but will be located in the Stellenbosch lab. The appointment is for one year with the possibility of renewal contingent upon satisfactory progress. Salary is competitive but benefits are not included. This position is available immediately.

Expressions of interest should be sent to Terry Robinson ( and should include the names and contact details of 2-3 referees, a full CV and a covering letter that highlights the appropriateness of your expertise and why you are interested in the position.

Professor Terence J. Robinson
Evolutionary Genomics Group
Stellenbosch University
Private Bag X1
Matieland 7602
South Africa
Tel: +27 21 808 39 55
Fax: +27 21 808 24 05

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