lunes, 12 de octubre de 2015


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Institución:Centro Nacional de Biotecnologia - CSIC
Proposal for a postdoctoral project (Severo Ochoa plan Centro Nacional de Biotecnologia - CSIC, Madrid, Spain)

Our group is looking for a motivated postdoc to apply to a competitive call for one of eleven 2-year postdoctoral fellowships in our institute

We are studying the host cell recognition of bacteriophage fibre and tailspike proteins. Bacteriophage tail fibres may be used to detect bacteria, while their cell-wall degrading proteins may be used to weaken or kill them. The project aims to solve the high-resolution structures of these phage proteins by X-ray crystallography in complex with their binding partners and substrates. During the last few years we have solved the structures of the homo-trimeric receptor-binding domains of the bacteriophage T4, T5 and T7 tail fibres - one of each of the Myoviridae, Siphoviridae and Podoviridae. Each of these proteins presented new folds and suggested which parts of the structure are involved in receptor binding.
Bacteriophages express enzymes during their infection cycle that target their host bacteria in different ways. Examples are receptor-binding tailspikes that hydrolyse outer cell wall components so the phage can access the membrane in the first step of infection, and endolysins to digest the bacterial peptidoglycan layer in order for the bacteriophage progeny to escape from the cell. During the last year, we have solved the structure of the CHAP domain of the Staphylococcal lysin produced by bacteriophage K. Targets are endolysins of several pathogenic bacteria.
Related recent publications:
- Singh et al. (2015) PLoS One 10, e0139339.
- Singh et al. (2014) PLoS One 9, e114373.
- Garcia-Doval & van Raaij (2012) Proc Natl Acad Sci USA 109, 9390-9395.
- Bartual et al. (2010) Proc Natl Acad Sci USA 107, 20287-20292.
Interested candidates with a doctorate degree and a competitive publication record, please send a full CV before November 30th (call deadline is 15 December 2015) to:
Mark J. van Raaij, CNB-CSIC, Madrid;

Información complementaria de la oferta:
Call text:
The CNB is seeking for highly talented and motivated post- doctoral scientists who wish to continue their career in one of the leading Spanish research centres in the Life Sciences
Up to 11 postdoctoral positions available
The CNB aims to incorporate up to eleven postdoctoral scientists through two-year working contracts, financed by a Severo Ochoa Centres of Excellence grant. Contracts include social security coverage and a competitive salary according to qualification and experience.
Applicants must hold a doctorate degree; postdoctoral research experience and a competitive publication track record will be additional assets.
Successful candidates will be notified by February 8 and should join the CNB before July 1, 2016.
Apply before December 15, 2015
Candidates should submit their applications by e-mail to, attaching the following documents:
• CURRICULUM VITAE, including academic information, list of publications, work experience, fellowships, research awards and other relevant merits.
CNB (maximum of 2 pages). Candidates are required to discuss the proposal with
their prospective group leader at the CNB before submitting the application. • STATEMENT OF ACCEPTANCE signed by the prospective CNB group leader.
Applicants should submit information in English (CV, research proposal, statement of acceptance, letters of recommendation). If the PhD certificate is not in English or Spanish, applicants should provide a translation in any of these languages.
Please note that all information should be submitted by December 15. Incomplete applications will not be considered.
For more information, please refer to the CNB web site at or contact us at

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