[OFER-TRABEC] NAC: CONVOCATORIA MOLECULAR MICROBIOLOGY

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---Procedencia:
Institución:INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI
Contacto correo-e:mvalls@fiispv.cat
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We are looking for a PhD student with expertise in Molecular Microbiology, genomic bioinformatics analyses and with a good English level. The thesis will be dedicated to analyse the genomes of a complete genus of a bacteria with consider to be formed by emerging pathogenic species.

Whole genome analysis of Aeromonas spp.

Aeromonas spp. are common aquatic bacteria that have increasingly been implicated in serious human and fish infections. The majority of human Aeromonas infections result in self-limiting gastroenteritis or superficial skin infections. However, more threatening systemic infections include bacteremia, cellulitis, peritonitis, hemolytic-uremic syndrome and necrotizing fasciitis. Also several Aeromonas species are fish pathogens that negatively impact the fishing industry. In the last 10 years reliable molecular identification methods have enabled the discovery of new Aeromonas species and have provided evidence of a greater diversity of species involved in clinical and environmental samples than was previously thought on the basis of using biochemical tests.
Now in the genomic era whole genome derived information can provide data for identification to species level, may help to identify many virulence determinants for the recognition of pathogenic strains and may help to recognize specific genes that bacteria may use to adapt to different environments. There are more than 40 Aeromonas genomes available in public databases. However, these genomes are mainly from non type strains. In bacterial taxonomy type strains are used as reference strains by the scientific community for a correct identification and for the discovery of new species. This project aims at obtaining whole-genome sequences of the type strains of the 27 Aeromonas species that now compose the genus in order to perform phylogenomics analyses and to detect novel virulence factors and metabolic routes that may help to understand the virulence potential and their adaptation to the different hosts and environments.



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Información complementaria de la oferta:
Interesados enviar CV antes del 30 de Agosto

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