[OFER-TRABEC] NAC: Candidate for Beatriu Pin=?ISO-8859-1?Q?=C3=B3s_?=Postdoctoral Contract

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---Procedencia:
Institución:IDIBELL
Contacto correo-e:eballestar@idibell.cat
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POSITION

A motivated Postdoctoral Candidate is seeked to apply to a 'Beatriu de Pinós' Postdoctoral Contract to join the group of Dr. Esteban Ballestar within the Cancer Epigenetics and Biology Programme (PEBC) at the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona.

The primary goal of Esteban Ballestar's laboratory is devoted to the study of mechanisms of epigenetic regulation in myeloid differentiation, with relation to both autoimmune and autoinflammatory diseases. A multidisciplinary approach using cell cultures, clinical samples and cutting edge epigenetic, molecular biology and cell biology techniques will be used.

To apply the Beatriu de Pinós programme, the candiate should have obtained his/her PhD degree between January 1 2009 and December 31 2014, have a mínimum of 2 year postdoctoral experience and have worked outside Spain at least 2 years during the past 3 years. More details in http://dogc.gencat.cat/ca/pdogc_canals_interns/pdogc_resultats_fitxa/?action=fitxa&documentId=756921.

The call is very competititive. The candidate should have at least a minimum of a first author article with IF>8 during his previous postdoctoral period (last 2-3 yeasr) to be considered as a potential candidate.

RESEARCH PROJECT

Our laboratory research focuses on the study of the role, targeting mechanisms and functional consequences of epigenetic modifications in the acquisition of identity and function of immune cells. A particular emphasis is given to the study of DNA methylation. This study includes the study of the interplay between the DNA methylation and demethylation machinery and transcription factors, and their links to upstream cell signaling pathways and extracellular factors. In addition our group investigates the relationship between DNA methylation changes and histone modifications. For this purpose, the group has developed several cellular models to investigate epigenetic mechanisms in the context of myeloid differentiation [Alvarez-Errico et al (2015) Nat Rev Immunol; de la Rica et al (2013) Genome Biol; Vento-Tormo et al (2016) Genome Biol], not only in physiological conditions but also under inflammatory situations or other pathological contexts those in cancer, autoimmune and auto
inflammatory diseases and others, such as the ones leading to the development of innate immune memory like in sepsis.

In addition to the study of experimental models, the team investigates the occurrence of aberrant epigenomic (methylome) profiles in the context of autoimmune and autoinflammatory diseases, as well as in certain types of primary immunodeficiencies. In these contexts, the group has been pioneer and published the first reports on the existence of epigenetic defects in these diseases. Examples include publications describing the presence of DNA methylation alterations in SLE [Javierre et al (2010) Genome Res] and common variable immunodeficiency [Rodriguez-Cortez et al (2015) Nature Commun], using discordant pairs of monozygotic twins, and in Cryopyrin-Associated Periodic Syndromes (CAPS), an archetypical autoinflammatory disease [Vento-Tormo et al (2016) J Allergy Clin Immunol].


GROUP LEADER

Dr. Esteban Ballestar
Chromatin and Disease Group, Leader
Cancer Epigenetics and Biology Programme (PEBC)
Bellvitge Biomedical Research Institute (IDIBELL)
Avda. Gran Via 199-203
08908 L'Hospitalet de Llobregat, Barcelona, Spain
E-mail: eballestar@idibell.cat


FUNDING

Esteban Ballestar's team is funded by several public national and international grants including the Spanish National Plan, the Innovative Medicines Initiave (IMI) Programme, or the FP7 cooperation programmes of the European Union or private foundations like the Ramon Areces Foudnation or Multiple Myeloma Research Foundation (MMRF).

SELECTED RESEARCH PUBLICATIONS

Álvarez-Errico, D., Vento-Tormo, R., Sieweke, M. and Ballestar, E. (2015) Epigenetic control in myeloid cell differentiation, identity and function. Nature Reviews Immunology 15, 7–17.

Javierre, B.M., Fernandez, A.F., Richter, J., Al-Shahrour, F., Martin-Subero, J.I., Rodríguez-Ubreva, J., Berdasco, M., Fraga, M.F., O'Hanlon, T.P., Rider, L.G., Jacinto, F.V., Lopez-Longo, F.J., Dopazo, J., Forn, M., Peinado, M.A., Carreño, L., Sawalha, A.H., Harley, J.B., Siebert, R., Esteller, M., Miller, F.W., and Ballestar, E. (2010) Changes in the Pattern of DNA Methylation Associate with Twin Discordance in Systemic Lupus Erythematosus. Genome Research 20, 170-179.
De la Rica, L., Rodríguez-Ubreva, J., García, M., Islam, A., Urquiza, J.M., Hernando, H., Christensen, J., Helin, K., Gómez-Vaquero, C., and Ballestar, E. (2013) PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biology 14, R99.

Rodríguez-Cortez, V.C., del Pino-Molina, L., Rodríguez-Ubreva, J., Ciudad, L., Gómez-Cabrero, D., Company, C., Urquiza, J.M., Tegnér, J., Rodríguez-Gallego, C., López-Granados, E., and Ballestar, E. (2015) Monozygotic Twins Discordant for Common Variable Immunodeficiency Reveal Impaired DNA Demethylation during Naïve-to-Memory B-Cell Transition. Nature Communications 6, 7335.

Vento-Tormo, R., Company, C., Rodríguez-Ubreva, J., de la Rica, L., Urquiza, J.M., Javierre, B.M., Sabarinathan, R., Luque, A., Esteller, M., Aran, J.M., Álvarez-Errico, D. and Ballestar, E. (2016) IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation. Genome Biology 17, 4.

Vento-Tormo, R., Álvarez-Errico, D., Garcia-Gomez, A., Hernández-Rodríguez, J., Buján, S., Basagaña, M., Méndez, M., Yagüe, J., Juan, M., Aróstegui, J.I., and Ballestar, E. (2016) DNA demethylation of inflammasome-associated genes is enhanced in Cryopyrin-Associated Periodic Syndromes. The Journal of Allergy and Clinical Immunology. Jul 6. pii: S0091-6749(16)30424-9.

LAB WEBSITE:

http://www.idibell.cat/modul/chromatin-and-disease/en


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Información complementaria de la oferta:
Inquiries to:

Dr. Esteban Ballestar
Chromatin and Disease Group, Leader
Cancer Epigenetics and Biology Programme (PEBC)
Bellvitge Biomedical Research Institute (IDIBELL)
Avda. Gran Via 199-203
08908 L'Hospitalet de Llobregat, Barcelona, Spain
E-mail: eballestar@idibell.cat